Role of Psidium Guajava Leaf Extract in Alcohol Induced Hepatopathy of Albino Rat

Healthy Albino Rats (Wister variety) of either sex are reared feeding on pulses, gram and bread. After acclimatization these are divided into one normal-control and three experimental groups. Alcoholic hepatitis is induced in two of the experimental groups by oral administration of 30% ethanol for eight weeks. Oral administration of water-extract of Psidium guajava leaves is done to one non-alcoholic and one alcoholic group of Rats throughout the study period. Investigation of AST (Aspartate Transferase), ALT (Alanine Transferase), ALP (Alkaline Phosphatase) activities in blood serum and Liver Lipid Peroxide after the experimental period leads to a conclusion that P. guajava leaf-extract may play a good role in stopping hepatocyte destruction due to alcoholic injury. Urea, Creatinine and Uric Acid levels in blood serum and GST (Glutathione S-Transferase) and CYP (Cytochrome p450) activity in liver of the study animals indicate that no major toxicity arise from the administration of P. guajava leaf-extract.